Hans D Ochs, MD

Hans D Ochs, MD

Specialties

  • Academic Title: Professor, Pediatrics
  • Research Title: Principal Investigator
  • Foundation Title: Jeffrey Modell Endowed Chair in Pediatric Immunology Research
  • Research Center: Center for Immunity and Immunotherapies
  • On Staff Since: February 1974
"I decided to enter the medical profession because the Hippocratic Oath rendered it unique, apolitical and not money-driven; at the same time, medicine promised to be a field where research has a purpose, teaching has an impact and providing care for patients is considered a privilege and a vocation. I am content and happy I did."

  • Biography

    Hans D. Ochs, MD, is attending physician at Seattle Children’s Hospital. He earned his MD summa cum laude from the University of Freiburg, Germany. He completed his residency in pediatrics at the University of Washington.

    The focus of his research is the molecular definition of primary immunodeficiency diseases (PIDD) and the investigation of new techniques to confirm the diagnosis. He and his collaborators contributed significantly to the identification of a number of genes associated with PIDD located on the X chromosome (CD40L, Wiskott-Aldrich syndrome protein [WASP], FOXP3, gp91phox) or on autosomes (uracil-DNA glycosulase; Rag1, Rag2 hypomorphic mutations as the cause of Omenn syndrome, STAT3 responsible for AD-HIES). Ochs started the Immunodeficiency Clinic at Seattle Children’s in 1985, providing evaluation and care for both pediatric and adult patients with immunodeficiency disorders. He has initiated clinical trials for new immunoglobulin preparations for intravenous and subcutaneous infusions and has collaborated with the bone marrow transplant team in the design of new protocols for stem cell transplant and gene therapy. He was principal investigator for U.S. Immune Deficiency Network (USIDnet) and is co-founder and member of the summer school faculty devoted to primary immune deficiencies. He is principal editor for the medical textbook Primary Immunodeficiency Diseases: A Molecular and Genetic Approach and co-editor for Immunological Disorders in Infants and Children.

    Board Certification(s)

    Pediatrics
    Allergy & Immunology

    Education

    Albert-Ludwigs Universitat Freiburg, D-79110 Freiburg Im Breisgau

    Residency

    University of Washington School of Medicine, Seattle, WA

    Fellowship

    University of Washington School of Medicine, Seattle, WA

    Research Description

    Dr. Ochs' research focuses on the molecular basis of Primary Immune Deficiency Diseases with special interest in the genes that have been linked to the Wiskott Aldrich Syndrome, Hyper IgM syndromes, X-linked Agammaglobulinemia, IPEX syndrome, autosomal recessive Hyper IgE syndrome. To improve the long-term outcome of these disorders, he has actively participated in clinical trials to develop immunoglobulin replacement, hematopoietic stem cell transplantation, and gene therapy.

    Dr. Ochs' clinical interests focus on the use of intravenous and subcutaneous immunoglobulin and the in vivo analysis of antibody production using Bacteriophage FX174. He and his collaborators contributed to the identification of several genes associated with PIDD located on the X chromosome, including CD40L, Wiskott-Aldrich Syndrome protein, BTK, and FOXP3.

    Recently, he focused on the gene Uracil-DNA Glycosulase, causing a rare form of autosomal recessive hyper IgM syndrome and on STAT3, the gene causing autosomal dominant Hyper IgE Syndrome if mutated. In 1995, he moved the immunodeficiency clinic from the University to Children's Hospital, providing diagnostic evaluations and clinical care for both pediatric and adult patients with PIDD. He initiated and maintained a successful cooperation with the bone marrow transplant unit since the early 70s and participated in the design of protocols related to stem cell transplantation for patients with SCID, Wiskott-Aldrich Syndrome, GGD, and Hyper IgM Syndrome.

    He is a PI for the NIH contract supporting the United States Immune Deficiency Network (USIDNet) and member of the U.S. Summer School Faculty devoted to teaching fellows interested in primary immunodeficiency diseases. As co-editor of the textbooks Primary Immunodeficiency Diseases, A Molecular and Genetic Approach, 2nd Edition and for Immunologic Disorders in Infants and Children, 3rd Edition.

    The Ochs/Torgerson Lab focuses on:

    1) The molecular basis of primary immunodeficiency disorders
    2) Autoimmunity and Immune dysregulation
    3) Regulatory T cells and mutations of FOXP3
    4) Eventual consequences of heterozygous hypermorphic STAT3 mutations and their relationship to autosomal dominant Hyper IgE syndrome.

    Research Focus Area

    Immunology

  • Patient Testimonials

  • Awards and Honors

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  • Publications

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