Lisa M Frenkel, MD

Lisa M Frenkel, MD

Specialties

  • Biography

    Dr. Lisa Frenkel is an internationally recognized expert on HIV and infectious disease. She is Co-Director of the Center for Global Infectious Disease Research at Seattle Children's Research Institute; Professor of Pediatric Infectious Diseases, Laboratory Medicine and Pathology at the University of Washington; and co-director of Seattle Children's Pediatric Infectious Diseases and Virology Clinics.

     

    Professor of Pediatrics and Laboratory Medicine and Pathology, Member Division of Infectious Diseases and Co-Director of Seattle Children’s Research Institute’s (SCRI) Center for Global Infectious Disease Research (CGIDR).

    EDUCATION:

    1976                   Universidad de Costa Rica, San Jose

    1977                   B.A., Kansas University, Lawrence, Kansas

    1981                   M.D., Kansas University Medical School, Kansas City, Kansas

    POSTGRADUATE TRAINING:

    1981-1984          Pediatric Residency, University of California, Los Angeles, California

    1984-1987          Infectious Disease Fellowship, University of California, Los Angeles, California

    FACULTY POSITIONS HELD (since 1999):

    1999-present      Director, HIV-1 Drug Resistance Testing for University WA Clinical Laboratory

    2003-present      Professor of Pediatrics, University of Washington, Seattle Children’s Hospital, Seattle, Washington

    2003-present      Professor of Laboratory Medicine, University of Washington, Seattle, Washington

    2010-present      Affiliate Investigator, Vaccine and Infectious Disease Division of the Fred Hutchinson Cancer Research Center, Seattle, Washington

    Board Certification(s)

    Pediatric Infectious Diseases
    Pediatrics

    Education

    University of California Los Angeles, Los Angeles, CA
    University of Kansas at Lawrence, Lawrence, KS

    Residency

    David Geffen School of Medicine at UCLA, Los Angeles, CA

    Clinical Interests

    Prevention and treatment of pediatric HIV disease, neonatal herpes simplex virus (HSV) and congenital cytomegalovirus (CMV) infections

    Research Description

    Over the past 30 years, our group has conducted research projects in Peru, Thailand, Mozambique, Kenya, Uganda and South Africa. In close concert with our collaborators our studies have aimed to address practical questions related to the prevention of HIV-1 infection in infants, mechanisms leading to shedding of virus in breast milk and genital tract of adults, treatment of drug-resistant virus in children and adults and understanding mechanisms underlying the persistence of HIV infection despite effective antiretroviral treatment. Additionally, we have developed economical assays with the goal of making testing accessible to resource-poor communities, to improve the management of HIV infection.

    When studying transmitted resistance from HIV-infected mothers to their children, our group noted a series of errors that refuted the concept of transient HIV infection occurring in infants (Frenkel et al. Science, 1998; PMID9582120). Our findings in this study cemented the importance of meticulous Laboratory Quality Assurance in our research and clinical work. Our group has operated a CLIA Laboratory for >17 years primarily performing assays NIH IMPAACT Network.

    Our laboratory located within SCRI found evidence and later provided proof that proliferating cells have a major role in sustaining the HIV reservoir despite effective treatment (J Virol 2005, PMID16014925) (Science 2014, PMID25011556Research Focus Area

    Infectious Disease, Virology

  • Related Resources

    • Frenkel Lab

      Frenkel Lab

      The Frenkel Lab aims to: understand the mechanisms that allow HIV to persist during antiretroviral therapy; develop practical, affordable tests to detect drug-resistant HIV; make insights into reservoirs of drug-resistant HIV and illuminate the pathogenesis of HIV-related diseases.

    • My Bibliography - NCBI

      For a list of my publications, please access MyBibliography.

  • Patient Testimonials

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  • Awards and Honors

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  • Publications

  • Presentations

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  • Research Funding

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  • Clinical Trials and Research

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