Brain Tumor Resource Lab
The Brain Tumor Resource Lab strives to generate and distribute patient-derived xenograft models and cell lines. Our focus is on pediatric brain tumors.
The figure at right depicts the best-characterized models for comparison. Click on it for a larger version.
Please note that the tissue culture lines should not be implanted into mice and patient-derived xenograft cell lines should not be used for tissue culture.
These resources are for academic use only. Please contact us if you are interested in other uses.
Similar to ATCC, the only way to obtain these lines is to place an order through this site. This ensures that we can contact you if important information needs to be conveyed, that you understand that the lines cannot be shared, that a material transfer agreement is in place and that we can track how these lines are used to benefit science and medicine.
We gratefully acknowledge funding from the National Institutes of Health, Seattle Run of Hope, the German Cancer Consortium (DKTK), and the German Cancer Research Center (DKFZ), Heidelberg, Germany.
Resources
- BTRL Cell Line Detailed Information by Disease or Genetics (XLS)
- Models Maintained by Other Institutions (XLS)
BTRL Cell Line Information
Note: Please check the order sheet to see the availability for the cell lines below. Some cell lines might not be immediately available and will be processed on an as-available basis.
Medulloblastoma Lines
Tumor Classification
Medulloblastoma, Group 3: 17p, 9q, PTCH1
Available As
Mouse Xenograft
Tumor Classification
Medulloblastoma, Group 3: 17p
Available As
Mouse Xenograft
mCherry/luciferase Mouse Xenograft
Tissue Culture Line
Tumor Classification
Tumor Classification
Tumor Classification
Tumor Classification
Medulloblastoma, Group 3: MYC, 17p, 17q, 9p
Available As
Mouse Xenograft
mCherry/luciferase Mouse Xenograft
Tissue culture line available
Tumor Classification
Tumor Classification
Medulloblastoma, Group 4: 17p, 17q, 9q
Available As
Mouse Xenograft
Tumor Classification
Medulloblastoma, SHH: TP53, MYCN, GLI2, 17p, 17q, 9q
Available As
Mouse Xenograft
mCherry/luciferase Mouse Xenograft
Tumor Classification
Medulloblastoma, Group 3: MYC, 17q, 17p
Available As
Mouse Xenograft
mCherry/luciferase Mouse Xenograft
Tissue culture line available
Tumor ClassificationHas not yet been characterized.
Tumor Classification
Medulloblastoma, SHH: TP53, MYCN, GLI2, 17p, 17q, 9q
Available As
Mouse Xenograft
Tumor Classification
Medulloblastoma, Group 3: KBTBD4, 17p, 17q, 9q
Available As
Mouse Xenograft
High Grade Glioma Lines
Tumor Classification
High Grade Glioma, K27: EGFR, H3FA/HIST1H3B
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma, pedRTK1: CDK4, FGFR1-4, MDM2
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma, K27: ATRX, H3FA/HIST1H3B, SETD1A, TP53
Available As
Mouse Xenograft
Tumor Classification
Tumor Classification
High Grade Glioma, MYCN: ID2, MYCN, EGFR, PIK3R1, MGMT methylation
Available As
Mouse Xenograft
Tissue Culture
Tumor Classification
High Grade Glioma, PedRTK1: CDK4, PDGFRA, TERT, TP53
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma, pedRTK1: ATRX, EGFR, FGFR1-4, MGMT metylation, MSH2, hypermutator
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma, pedRTK1: ATRX, EGFR, FGFR1-4, MSH2, hypermutator
Available As
Mouse Xenograft
Tumor Classification
High Grade Glioma
Available As
Mouse Xenograft
Has not been characterized, TC line only
Tumor Classification
Astrocytoma
Has not been characterized, TC line only
Tumor Classification
High Grade Glioma
Ependymoma Lines
Tumor Classification
Ependymoma, PFA: 1q
Available As
Mouse Xenograft
Tissue Culture Line
Tumor Classification
Ependymoma
Both Tissue Culture and PDX cell lines available
Tumor Classification
Ependymoma
Available As
PDX Cell Line
Tumor Classification
Ependymoma, RELA fusion: CDKN2A/B, RELA
Available As
Mouse Xenograft
Pineoblastoma Cell Lines
Tumor ClassificationNeuroblastoma Cell Lines
Patient Derived Xenograft grown in Flank.
Atypical Teratoid Rhabdoid Tumor Cell Lines
Tumor Classification
Atypical Teratoid Rhabdoid, SHH: SMARCB1
Available As
Mouse Xenograft
Tissue Culture Line
Tumor Classification
Atypical Teratoid Rhabdoid, SHH: SMARCB1
Available As
Mouse Xenograft
Tumor Classification
Atypical Teratoid Rhabdoid, MYC: SMARCB1
Available As
Mouse Xenograft