Oral Immunization with HIV-1 Envelope SOSIP trimers elicits systemic immune responses and cross-reactive anti-V1V2 antibodies in non-human primates.

Fisher BS, Dambrauskas N, Trakhimets O, Andrade DV, Smedley J, Sodora DL, Sather DN.

PLoS One , 2020 May 29: 15 (5 ) e0233577 PMCID: PMC7259690 View on PubMed

Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection.

Wood MP, Wood LF, Templeton M, Fisher B, Lippy A, Jones CI, Lindestam Arlehamn CS, Sette A, Fuller JT, Murapa P, Jaspan HB, Fuller DH, Sodora DL.

J Infect Dis. , 2019 Oct 12: jiz382 View on PubMed

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.

30655382 J Virol. , 2019 Jan 17: 93 (3 ) PMCID: PMC6340051 View on PubMed

Feeding-Related Gut Microbial Composition Associates With Peripheral T-Cell Activation and Mucosal Gene Expression in African Infants.

Wood LF, Brown BP, Lennard K, Karaoz U, Havyarimana E, Passmore JS, Hesseling AC, Edlefsen PT, Kuhn L, Mulder N, Brodie EL, Sodora DL, Jaspan HB.

29659737 Clin Infect Dis. , 2018 Sep 28: 67 (8 ) 1237-1246 PMCID: PMC6455922 View on PubMed

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.

29997216 J Virol. , 2018 Aug 29: 92 (18 ) PMCID: PMC6146711 View on PubMed

Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr., Silvestri G, Chahroudi A, Klatt NR, Sodora DL.

PLoS Pathog , 2018 Feb 21: 14 (2 ) e1006871 PMCID: PMC5837102 View on PubMed

Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.

Palesch D, Bosinger SE, Tharp GK, Vanderford TH, Paiardini M, Chahroudi A, Johnson ZP, Kirchhoff F, Hahn BH, Norgren RB Jr., Patel NB, Sodora DL, Dawoud RA, Harris RA, Liu Y, Raveendran M, Han Y, English A, Thomas GWC, Hahn MW, Pipes L, Mason CE, Muzny DM, Gibbs RA, Sauter D, Worley K, Rogers J, Silvestri G.

Nature. , 2018 Jan 3: 553 (7686 ) 77-81 PMCID: PMC5843367 View on PubMed

T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin-A Exposure.

Wood LF, Wood M, Fisher B, Jaspan HB, Sodora DL.

Front Immunol. , 2017 Dec 22: 8 1857 PMCID: PMC5743911 View on PubMed

Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques.

Steele AK, Carrasco-Medina L, Sodora DL, Crawley AM.

PLoS One , 2017 Dec 19: 12 (12 ) e0188427 PMCID: PMC5736176 View on PubMed

BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.

Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL, and Jaspan, HB.

JCI Insight , 2017 Apr 6: 2 (7 ) e91963 PMCID: PMC5374072 View on PubMed

Non-pathogenic SIV and pathogenic HIV infections associate with disparate innate cytokine signatures in response to Mycobacteria bovis BCG.

Gasper MA, Biswas SP, Fisher BS, Ehnert SC, Sherman DR, Sodora DL.

PLoS One , 2016 Aug 9: 11 (8 ) e0158149 PMCID: PMC4978473 View on PubMed

Reduced SIV replication in macrophages of sooty mangabeys is associated with increased expression of host restriction factors.

Mir KD, Mavigner M, Wang C, Paiardini M, Sodora DL, Chahroudi AM, Bosinger SM, Silvestri G.

J Virol , 2015 Oct.: 89 (20 ) 10136-44 PMCID: PMC4580171 View on PubMed

Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants.

Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JS, Sodora DL, Gray CM, Jaspan HB.

Vaccine , 2015 Sep 11: 33 (38 ) 4782-9 PMCID: PMC4562895 View on PubMed

Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.

Kilgore KM, Murphy MK, Burton SL, Wetzel KS, Smith SA, Xiao P, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Hunter E, Collman RG, Amara RR, Derdeyn CA.

J Virol , 2015 Aug.: 89 (16 ) 8130-51 PMCID: PMC4524250 View on PubMed

Delaying BCG vaccination until 8 weeks of age results in robust BCG-Specific T-cell Responses in HIV-exposed infants.

Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB.

J Infect Dis , 2015 Feb 1: 211 (3 ) 338-46 PMCID: PMC4318913 View on PubMed

DNA/MVA and protein-based SIV vaccine regimens delivered to Rhesus macaques with novel adjuvants fail to elicit neutralizing antibodies with breadth.

Kilgore KM, Murphy MK, Wetzel KS, Smith SA, Burton SL, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Collman RG, Amara RR, Derdeyn CA.

AIDS Res Hum Retrov. , 2014 Oct.: 30 Suppl 1 A84

Lack of chronic immune activation during natural host SIV infection.

Sundaravaradan V, Gasper MA, Mir KD, and Sodora DL.

Natural Hosts of SIV. , 2014 Jul 25: 217-233. Ed. Ansari A and Silvestri G.

In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants.

Kidzeru EB, Hesseling AC, Passmore JA, Myer L, Gamieldien H, Tchakoute CT, Gray CM, Sodora DL, Jaspan HB.

AIDS , 2014 Jun 19: 28 (10 ) 1421-30 PMCID: PMC4333196 View on PubMed

Natural killer cell and T-cell subset distributions and activation influence susceptibility to perinatal HIV-1 infection.

Gasper MA, Kunwar P, Itaya G, Lejarcegui N, Bosire R, Maleche-Obimbo E, Wamalwa D, Slyker J, Overbaugh J, Horton H, Sodora DL, John-Stewart G, Lohman-Payne B.

AIDS , 2014 May 15: 28 (8 ) 1115-24 PMCID: PMC4365995 View on PubMed

Link between primate lentiviral coreceptor usage and Nef function.

Schmökel J, Li H, Shabir A, Yu H, Geyer M, Silvestri G, Sodora DL, Hahn BH, Kirchhoff F.

Cell Rep , 2013 Nov 27: 5 (4 ) 997-1009 PMCID: PMC4133736 View on PubMed

Early detection of simian immunodeficiency virus in the central nervous system following oral administration to rhesus macaques.

Milush JM, Chen HL, Atteberry G, Sodora DL.

Front Immunol , 2013 Aug 14: 4 236 PMCID: PMC3743037 View on PubMed

Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection.

Sundaravaradan V, Saleem R, Micci L, Gasper MA, Ortiz AM, Else J, Silvestri G, Paiardini M, Aitchison JD, Sodora DL.

PLoS Pathog , 2013 Aug.: 9 (6 ) e1003441 PMCID: PMC3694849 View on PubMed

The oral mucosa immune environment and oral transmission of HIV/SIV.

Wood LF, Chahroudi A, Chen HL, Jaspan HB, Sodora DL.

Immunol Rev , 2013 July: 254 (1 ) 34-53. Review. PMCID: PMC3821196 View on PubMed

Impact of mucosal inflammation on oral simian immunodeficiency virus transmission.

Giavedoni LD, Chen HL, Hodara VL, Chu L, Parodi LM, Smith LM, Sexton V, Cappelli D, Sodora DL.

J Virol , 2013 Feb.: 87 (3 ) 1750-8 PMCID: PMC3554177 View on PubMed

Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.

Mir KD, Bosinger SE, Gasper M, Ho O, Else JG, Brenchley JM, Kelvin DJ, Silvestri G, Hu SL, Sodora DL.

J Virol , 2012 July: 86 (14 ) 7605-15 PMCID: PMC3416282 View on PubMed

Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.

Sundaravaradan V, Mir KD, Sodora DL.

Curr Opin HIV AIDS , 2012 March: 7 (2 ) 164-71. Review. PMCID: PMC3639317 View on PubMed

Cloning and analysis of sooty mangabey alternative coreceptors that support simian immunodeficiency virus SIVsmm entry independently of CCR5.

Elliott ST, Riddick NE, Francella N, Paiardini M, Vanderford TH, Li B, Apetrei C, Sodora DL, Derdeyn CA, Silvestri G, Collman RG.

J Virol , 2012 Jan.: 86 (2 ) 898-908 PMCID: PMC3255830 View on PubMed

Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.

Jaspan HB, Liebenberg L, Hanekom W, Burgers W, Coetzee D, Williamson AL, Little F, Myer L, Coombs RW, Sodora D, Passmore JA.

21940422 The Journal of infectious diseases , 2011 Nov 15: 204 (10 ) 1550-6 PMCID: PMC3192190 View on PubMed

Generalized immune activation and innate immune responses in simian immunodeficiency virus infection.

Bosinger SE, Sodora DL, Silvestri G.

Curr Opin HIV AIDS , 2011 Sept.: 6 (5 ) 411-8. Review. PMCID: PMC3261611 View on PubMed

Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques.

Durudas A, Chen HL, Gasper MA, Sundaravaradan V, Milush JM, Silvestri G, Johnson W, Giavedoni LD, Sodora DL.

Curr HIV Res , 2011 July: 9 (5 ) 276-88 PMCID: PMC3337698 View on PubMed

Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells.

Milush JM, Mir KD, Sundaravaradan V, Gordon SN, Engram J, Cano CA, Reeves JD, Anton E, O'Neill E, Butler E, Hancock K, Cole KS, Brenchley JM, Else JG, Silvestri G, Sodora DL.

J Clin Invest , 2011 March: 121 (3 ) 1102-10 PMCID: PMC3049370 View on PubMed

Naïve and memory B cells in the rhesus macaque can be differentiated by surface expression of CD27 and have differential responses to CD40 ligation.

Kuhrt D, Faith S, Hattemer A, Leone A, Sodora D, Picker L, Borghesi L, Cole KS.

J Immunol Methods , 2011 Jan 5: 363 (2 ) 166-76 PMCID: PMC3357916 View on PubMed

SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase.

Mir KD, Gasper MA, Sundaravaradan V, Sodora DL.

Microbes Infect , 2011 Jan.: 13 (1 ) 14-24. Review. PMCID: PMC3022004 View on PubMed

A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.

Riddick NE, Hermann EA, Loftin LM, Elliott ST, Wey WC, Cervasi B, Taaffe J, Engram JC, Li B, Else JG, Li Y, Hahn BH, Derdeyn CA, Sodora DL, Apetrei C, Paiardini M, Silvestri G, Collman RG.

PLoS Pathog , 2010 Aug 26: 6 (8 ) e1001064 PMCID: PMC2928783 View on PubMed

Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.

Engram JC, Cervasi B, Borghans JA, Klatt NR, Gordon SN, Chahroudi A, Else JG, Mittler RS, Sodora DL, de Boer RJ, Brenchley JM, Silvestri G, Paiardini M.

Blood , 2010 Aug 5: 116 (5 ) 748-58 PMCID: PMC2918331 View on PubMed

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.

Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm MK, Villinger F, Piatak M Jr, Lifson JD, Assouline B, Morre M, Picker LJ, Sodora DL.

J Immunol , 2010: 185 (3 ) 1650-9 PMCID: PMC3050806 View on PubMed

Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.

Harris LD, Tabb B, Sodora DL, Paiardini M, Klatt NR, Douek DC, Silvestri G, Müller-Trutwin M, Vasile-Pandrea I, Apetrei C, Hirsch V, Lifson J, Brenchley JM, Estes JD.

J Virol , 2010 Aug.: 84 (15 ) 7886-91 PMCID: PMC2897601 View on PubMed

Nonpathogenic simian immunodeficiency virus infection of sooty mangabeys is not associated with high levels of autologous neutralizing antibodies.

Li B, Stefano-Cole K, Kuhrt DM, Gordon SN, Else JG, Mulenga J, Allen S, Sodora DL, Silvestri G, Derdeyn CA.

J Virol , 2010 June: 84 (12 ) 6248-53 PMCID: PMC2876631 View on PubMed

HIV, mucosal tissues, and T helper 17 cells: where we come from, where we are, and where we go from here.

Sodora DL, Silvestri G.

Curr Opin HIV AIDS , 2010 March: 5 (2 ) 111-3 View on PubMed

Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population.

Kuhrt D, Faith SA, Leone A, Rohankedkar M, Sodora DL, Picker LJ, Cole KS.

J Virol , 2010 March: 84 (5 ) 2466-76 PMCID: PMC2820932 View on PubMed

Elevated levels of innate immune modulators in lymph nodes and blood are associated with more-rapid disease progression in simian immunodeficiency virus-infected monkeys.

Durudas A, Milush JM, Chen HL, Engram JC, Silvestri G, Sodora DL.

J Virol , 2009 Dec.: 83 (23 ) 12229-40 PMCID: PMC2786739 View on PubMed

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.

Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G.

Nat Med , 2009 Aug.: 15 (8 ) 861-5. Review. PMCID: PMC2782707 View on PubMed

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.

Okoye A, Park H, Rohankhedkar M, Coyne-Johnson L, Lum R, Walker JM, Planer SL, Legasse AW, Sylwester AW, Piatak M Jr, Lifson JD, Sodora DL, Villinger F, Axthelm MK, Schmitz JE, Picker LJ.

J Exp Med , 2009 Jul 6: 206 (7 ) 1575-88 PMCID: PMC2715089 View on PubMed

Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis.

Paiardini M, Cervasi B, Engram JC, Gordon SN, Klatt NR, Muthukumar A, Else J, Mittler RS, Staprans SI, Sodora DL, Silvestri G.

Blood , 2009 Jan 15: 113 (3 ) 612-21 PMCID: PMC2628369 View on PubMed

Simian immunodeficiency virus pathogenesis.

Sodora DL, Ross TM.

Curr HIV Res , 2009 Jan.: 7 (1 ) 1. Commentary. View on PubMed

IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment.

Leone A, Picker LJ, Sodora DL.

Curr HIV Res , 2009 Jan.: 7 (1 ) 83-90. Review. View on PubMed

Gamma/Delta T cell mRNA levels decrease at mucosal sites and increase at lymphoid sites following an oral SIV infection of macaques.

Kosub DA, Durudas A, Lehrman G, Milush JM, Cano CA, Jain MK, Sodora DL.

Curr HIV Res , 2008 Nov.: 6 (6 ) 520-30 PMCID: PMC2777980 View on PubMed

Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts.

Pandrea I, Sodora DL, Silvestri G, Apetrei C.

Trends Immunol , 2008 Sept.: 29 (9 ) 419-28. Review. PMCID: PMC2840226 View on PubMed

Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.

Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalid M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F.

PLoS Pathog , 2008 Jul 18: 4 (7 ) e1000107 PMCID: PMC2444047 View on PubMed

Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.

Klatt NR, Villinger F, Bostik P, Gordon SN, Pereira L, Engram JC, Mayne A, Dunham RM, Lawson B, Ratcliffe SJ, Sodora DL, Else J, Reimann K, Staprans SI, Haase AT, Estes JD, Silvestri G, Ansari AA.

J Clin Invest , 2008 June: 118 (6 ) 2039-49 PMCID: PMC2391063 View on PubMed

CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection.

Dunham RM, Cervasi B, Brenchley JM, Albrecht H, Weintrob A, Sumpter B, Engram J, Gordon S, Klatt NR, Frank I, Sodora DL, Douek DC, Paiardini M, Silvestri G.

J Immunol , 2008 Apr 15: 180 (8 ) 5582-92 PMCID: PMC2683429 View on PubMed

Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis.

Gordon SN, Dunham RM, Engram JC, Estes J, Wang Z, Klatt NR, Paiardini M, Pandrea IV, Apetrei C, Sodora DL, Lee HY, Haase AT, Miller MD, Kaur A, Staprans SI, Perelson AS, Feinberg MB, Silvestri G.

J Virol , 2008 April: 82 (7 ) 3725-35 PMCID: PMC2268472 View on PubMed

Immune activation and AIDS pathogenesis.

Sodora DL, Silvestri G.

AIDS , 2008 Feb 19: 22 (4 ) 439-46. Review. View on PubMed

Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infections.

Kosub DA, Lehrman G, Milush JM, Zhou D, Chacko E, Leone A, Gordon S, Silvestri G, Else JG, Keiser P, Jain MK, Sodora DL.

J Virol , 2008 Feb.: 82 (3 ) 1155-65 PMCID: PMC2224435 View on PubMed

Understanding the benign nature of SIV infection in natural hosts.

Silvestri G, Paiardini M, Pandrea I, Lederman MM, Sodora DL.

J Clin Invest , 2007 Nov.: 117 (11 ) 3148-54. Review. PMCID: PMC2045617 View on PubMed

Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.

Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.

J Exp Med , 2007 Sep 3: 204 (9 ) 2171-85 PMCID: PMC2118701 View on PubMed

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys.

Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G.

J Immunol , 2007 Sep 1: 179 (5 ) 3026-34 PMCID: PMC2365740 View on PubMed

Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host.

Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL.

J Immunol , 2007 Sep 1: 179 (5 ) 3047-56 View on PubMed

Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeys.

Apetrei C, Gautam R, Sumpter B, Carter AC, Gaufin T, Staprans SI, Else J, Barnes M, Cao R Jr, Garg S, Milush JM, Sodora DL, Pandrea I, Silvestri G.

J Virol , 2007 Aug.: 81 (15 ) 7913-23 PMCID: PMC1951324 View on PubMed

Mucosal innate immune response associated with a timely humoral immune response and slower disease progression after oral transmission of simian immunodeficiency virus to rhesus macaques.

Milush JM, Stefano-Cole K, Schmidt K, Durudas A, Pandrea I, Sodora DL.

J Virol , 2007 June: 81 (12 ) 6175-86 PMCID: PMC1900075 View on PubMed

Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.

Estes JD, Wietgrefe S, Schacker T, Southern P, Beilman G, Reilly C, Milush JM, Lifson JD, Sodora DL, Carlis JV, Haase AT.

J Infect Dis , 2007 Feb 15: 195 (4 ) 551-61 View on PubMed

Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis.

Sumpter B, Dunham R, Gordon S, Engram J, Hennessy M, Kinter A, Paiardini M, Cervasi B, Klatt N, McClure H, Milush JM, Staprans S, Sodora DL, Silvestri G.

J Immunol , 2007 Feb 1: 178 (3 ) 1680-91 View on PubMed

HIV and CXCR4 in a kiss of autophagic death.

Levine B, Sodora DL.

J Clin Invest , 2006 Aug.: 116 (8 ) 2078-80 PMCID: PMC1523409 View on PubMed

The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus.

Dunham R, Pagliardini P, Gordon S, Sumpter B, Engram J, Moanna A, Paiardini M, Mandl JN, Lawson B, Garg S, McClure HM, Xu YX, Ibegbu C, Easley K, Katz N, Pandrea I, Apetrei C, Sodora DL, Staprans SI, Feinberg MB, Silvestri G.

Blood , 2006 Jul 1: 108 (1 ) 209-17 PMCID: PMC1895834 View on PubMed

Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.

Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F.

Cell , 2006 Jun 16: 125 (6 ) 1055-67 View on PubMed

Perturbations of cell cycle control in T cells contribute to the different outcomes of simian immunodeficiency virus infection in rhesus macaques and sooty mangabeys.

Paiardini M, Cervasi B, Sumpter B, McClure HM, Sodora DL, Magnani M, Staprans SI, Piedimonte G, Silvestri G.

J Virol , 2006 Jan.: 80 (2 ) 634-42 PMCID: PMC1346860 View on PubMed

Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys.

Muthukumar A, Zhou D, Paiardini M, Barry AP, Cole KS, McClure HM, Staprans SI, Silvestri G, Sodora DL.

Blood , 2005 Dec 1: 106 (12 ) 3839-45 PMCID: PMC1895113 View on PubMed

Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals.

Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, Radziewicz H, Piedimonte G, Magnani M, Montroni M, Kaech SM, Weintrob A, Altman JD, Sodora DL, Feinberg MB, Silvestri G.

J Immunol , 2005 Mar 1: 174 (5 ) 2900-9 View on PubMed

Rapid dissemination of SIV following oral inoculation.

Milush JM, Kosub D, Marthas M, Schmidt K, Scott F, Wozniakowski A, Brown C, Westmoreland S, Sodora DL.

AIDS , 2004 Dec 3: 18 (18 ) 2371-80 View on PubMed

Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors.

Ylisastigui L, Coull JJ, Rucker VC, Melander C, Bosch RJ, Brodie SJ, Corey L, Sodora DL, Dervan PB, Margolis DM.

J Infect Dis , 2004 Oct 15: 190 (8 ) 1429-37 View on PubMed

Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect.

Smith SM, Mefford M, Sodora D, Klase Z, Singh M, Alexander N, Hess D, Marx PA.

AIDS , 2004 Aug 20: 18 (12 ) 1637-43 View on PubMed

The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters.

Van Rompay KK, Singh RP, Brignolo LL, Lawson JR, Schmidt KA, Pahar B, Canfield DR, Tarara RP, Sodora DL, Bischofberger N, Marthas ML.

J Acquir Immune Defic Syndr , 2004 Aug 1: 36 (4 ) 900-14 View on PubMed

CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment.

Van Rompay KK, Singh RP, Pahar B, Sodora DL, Wingfield C, Lawson JR, Marthas ML, Bischofberger N.

J Virol , 2004 May: 78 (10 ) 5324-37 PMCID: PMC400346 View on PubMed

An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory.

Saavedra-Lozano J, Cao Y, Callison J, Sarode R, Sodora D, Edgar J, Hatfield J, Picker L, Peterson D, Ramilo O, Vitetta ES.

Proc Natl Acad Sci USA , 2004 Feb 24: 101 (8 ) 2494-9 PMCID: PMC3566978 View on PubMed

Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression.

Muthukumar A, Wozniakowski A, Gauduin MC, Paiardini M, McClure HM, Johnson RP, Silvestri G, Sodora DL.

Blood , 2004 Feb 1: 103 (3 ) 973-9 View on PubMed

Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication.

Wang C, Pflugheber J, Sumpter R Jr, Sodora DL, Hui D, Sen GC, Gale M Jr.

J Virol , 2003 April: 77 (7 ) 3898-912 PMCID: PMC150642 View on PubMed

Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.

Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP, McClure HM, Staprans SI, Feinberg MB.

Immunity , 2003 March: 18 (3 ) 441-52 View on PubMed

In vivo analysis of Nef function.

Wei BL, Arora VK, Foster JL, Sodora DL, Garcia JV.

Curr HIV Res , 2003 Jan.: 1 (1 ) 41-50. Review. View on PubMed

Decreased levels of recent thymic emigrants in peripheral blood of simian immunodeficiency virus-infected macaques correlate with alterations within the thymus.

Sodora DL, Milush JM, Ware F, Wozniakowski A, Montgomery L, McClure HM, Lackner AA, Marthas M, Hirsch V, Johnson RP, Douek DC, Koup RA.

J Virol , 2002 Oct.: 76 (19 ) 9981-90 PMCID: PMC136511 View on PubMed

Regulation of PKR and IRF-1 during hepatitis C virus RNA replication.

Pflugheber J, Fredericksen B, Sumpter R Jr, Wang C, Ware F, Sodora DL, Gale M Jr.

Proc Natl Acad Sci USA. , 2002 Apr 2: 99 (7 ) 4650-5 PMCID: PMC123702 View on PubMed

Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys.

Sodora DL, Douek DC, Silvestri G, Montgomery L, Rosenzweig M, Igarashi T, Bernacky B, Johnson RP, Feinberg MB, Martin MA, Koup RA.

Eur J Immunol , 2000 April: 30 (4 ) 1145-53 View on PubMed

Immunization with a live, attenuated simian immunodeficiency virus vaccine leads to restriction of viral diversity in Rhesus macaques not protected from pathogenic challenge.

Sodora DL, Sheridan KE, Marx PA, Connor RI.

J Virol , 1999 May: 73 (5 ) 4443-6 PMCID: PMC104226 View on PubMed

Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks.

Sodora DL, Gettie A, Miller CJ, Marx PA.

AIDS Res Hum Retroviruses. , 1998 April: 14 Suppl 1 S119-23 View on PubMed

A genetic and viral load analysis of the simian immunodeficiency virus during the acute phase in macaques inoculated by the vaginal route.

Sodora DL, Lee F, Dailey PJ, Marx PA.

AIDS Res Hum Retroviruses. , 1998 Jan 20: 14 (2 ) 171-81 View on PubMed

Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades.

Bachmann MH, Mathiason-Dubard C, Learn GH, Rodrigo AG, Sodora DL, Mazzetti P, Hoover EA, Mullins JI.

J Virol. , 1997 June: 71 (6 ) 4241-53 PMCID: PMC191639 View on PubMed

Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys.

Chen Z, Luckay A, Sodora DL, Telfer P, Reed P, Gettie A, Kanu JM, Sadek RF, Yee J, Ho DD, Zhang L, Marx PA.

J Virol. , 1997 May: 71 (5 ) 3953-60 PMCID: PMC191547 View on PubMed

Analysis of a feline immunodeficiency virus provirus reveals patterns of gene sequence conservation distinct from human immunodeficiency virus type 1.

Sodora DL, Courcelle J, Brojatsch J, Berson A, Wang YC, Dow SW, Hoover EA, Mullins JI.

AIDS Res Hum Retroviruses. , 1995 April: 11 (4 ) 531-3 View on PubMed

Structure and function of glycoprotein D from herpes simplex virus.

Eisenberg RJ, Long D, Sodora DL, Chiang H-Y, Wilcox WC, Abrams WR, Muggeridge MI, and Cohen GH.

Frontiers in Virology. , 1994: 3:43-65. Ed. Becker Y and Darai G.

Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns.

Sodora DL, Shpaer EG, Kitchell BE, Dow SW, Hoover EA, Mullins JI.

J Virol. , 1994 April: 68 (4 ) 2230-8 PMCID: PMC236699 View on PubMed

Structural and functional studies of herpes simplex virus glycoprotein D.

Cohen GH, Muggeridge MI, Long D, Sodora DL, Eisenberg RJ.

Adv Exp Med Biol. , 1992 Jan.: 327 217-28. Review. View on PubMed

Absence of asparagine-linked oligosaccharides from glycoprotein D of herpes simplex virus type 1 results in a structurally altered but biologically active protein.

Sodora DL, Cohen GH, Muggeridge MI, Eisenberg RJ.

J Virol. , 1991 Aug.: 65 (8 ) 4424-31 PMCID: PMC248882 View on PubMed

Characterization of a recombinant herpes simplex virus which expresses a glycoprotein D lacking asparagine-linked oligosaccharides.

Sodora DL, Eisenberg RJ, Cohen GH.

J Virol. , 1991 Aug.: 65 (8 ) 4432-41 PMCID: PMC248883 View on PubMed

Influence of asparagine-linked oligosaccharides on antigenicity, processing, and cell surface expression of herpes simplex virus type 1 glycoprotein D.

Sodora DL, Cohen GH, Eisenberg RJ.

J Virol. , 1989 Dec.: 63 (12 ) 5184-93 PMCID: PMC251182 View on PubMed

The contribution of cysteine residues to antigenicity and extent of processing of herpes simplex virus type 1 glycoprotein D.

Wilcox WC, Long D, Sodora DL, Eisenberg RJ, Cohen GH.

J Virol. , 1988 June: 62 (6 ) 1941-7 PMCID: PMC253277 View on PubMed

Expression of herpes simplex virus type 1 glycoprotein D deletion mutants in mammalian cells.

Cohen GH, Wilcox WC, Sodora DL, Long D, Levin JZ, Eisenberg RJ.

J Virol. , 1988 June: 62 (6 ) 1932-40 PMCID: PMC253276 View on PubMed

Selected Publications

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